Robert Gerstman D.O., a member of the American
Osteopathic Association, provides the following
explanation. Dr. Gerstman, who specializes in
psychiatry, is board certified by the American
Osteopathic Board of Neurology and Psychiatry and the
American Board of Psychiatry and Neurology.
Before Magnetic Resonance Imaging
(MRI) entered the clinical arena in
1982, the only way to get any sort
of 3-D representation of the human
body was by using Computerized
Axial Tomography, otherwise known
as CAT or CT scans. Although CT
works well in certain contexts, it
has limitations. It exposes patients
to radiation and only shows the
body on its axial (top to bottom)
plane.
In contrast, MRI does not rely on the absorption of x-rays. It
is based instead on Nuclear Magnetic Resonance (NMR).
When MRI was first introduced in research, it was actually
called NMR. That name, though, scared many people who
incorrectly assumed that the technique would expose them
to nuclear radiation. In fact, the 'N' of NMR represents
atomic nuclei and how they spin, not nuclear radiation.
The basic physics involved is as follows: When atoms are
placed in a magnetic field, the odd-numbered atoms (those
having an unequal number of protons and neutrons, such as
hydrogen) align within this field. In other words, their axes
of rotation all point the same way. Hydrogen is the most
abundant odd-numbered atom in the body, but all
odd-numbered atoms are subject to this alignment process.
When these atoms are then exposed to a brief interruption of
the magnetic field (commonly referred to as a pulse), they
shift away from the magnetic field. After the pulse is lifted,
the atoms realign, emitting a radiofrequency signal.
Scanners in an MRI machine collect all the signals from the
individual nuclei and, with the help of computer analysis, use
that information to create a series of dimensional images.
Unlike CT, MRI can show pictures along many planes--the
axial plane, the saggital plane (side to side) and the coronal
plane (front to back)--enabling physicians to see images that
were previously impossible to visualize except during
autopsy. Of clinical significance, using different pulse signals
results in different image types. The three most commonly
used types are termed T1, T2 and proton density.
T1 is a short, fast pulse that makes fat tissue appear bright
and cerebral spinal fluid (CSF) dark. T1 images look like CT
images and are more focused than the other MRI image
types. T1 allows for the overall visualization of structures in
the body--a view that can be enhanced by using a contrast
medium. In the same way that iodine can be used in CT
scans to stain blood vessels, gadolinium diethyylenetrinine
pentaacetic acid (gadolinium DTPA) renders blood vessels in
a T1 MRI image white. (Gadolinium does not routinely cross
the blood-brain barrier unless the barrier has broken down
due to, say, tumors or infections.)
T2 pulses last four times as long as the T1 variety, which
makes hydrogen nuclei, surrounded by water, a more
suitable contrast. In T2 images, CSF appears white and areas
that have an abnormally high water content (those affected
by tumor, infection or stroke) look bright as well. In proton
density images, CSF and the brain look the same, making it
easier to see tissue changes next to ventricle structures.
In addition to their clinical versatility, MRI scanners seem to
cause no harm to biological tissue at exposures of 0.3-2.0
teslas of electromagnetic energy. And the technique has
numerous applications; new ones are being discovered all
the time. MRI can show atrophy changes of the brain
common in Alzheimer's Dementia. It can detect tumors at
earlier stages of development than many other forms of
medical imaging. And it better reveals parts of the body that
are not easily shown on the axial plane, including the
cerebellum, where telltale changes take place in Parkinson's
disease, Huntington's Chorea and Multiple Sclerosis.
Unfortunately, MRI can not be used for every patient. Those
with pacemakers and ferromagnetic metal implants are not
eligible. Also people with even mild claustrophobia can
experience great discomfort during an MRI scan, which
requires them to lie still inside a narrow tube. Increasingly
many open MRI machines, which don't have tubes, are
available. But the images they produce, though still superior
to CT scans, are not as sharp.
That said, CT scans are still an integral part of every hospital
system, particularly in emergency settings because they
don't take nearly as long as MRI scans to produce. Also, they
depict bone more clearly than MRI. So in cases of the
unconscious patient with possible head trauma, CT is the way
to go.